Scientists using gene therapy have partially restored hearing and balance in profoundly deaf mice, according to a study published on Monday in the journal Nature Medicine.
The research, still in its early stages and restricted to lab animals, may open up new avenues for tackling Usher syndrome, an inherited form of human deafness that usually goes hand in hand with blindness.
Researchers led by Michelle Hastings at the Rosalind Franklin University of Medicine and Science in Chicago, Illinois, aimed at a gene called USH1C which has been implicated in the "Type 1" form of Usher syndrome.
USH1C controls a protein called harmonin, which plays a vital role in hair cells -- the cells in the cochlea of the inner ear that respond to sound waves and send an electrical signal to the brain.
The team devised a tiny strand of genetic material called an antisense oligonucleotide to "switch off" a faulty version of the gene that produces truncated forms of the protein.
The therapy was injected in newborn mice that had been genetically engineered to have the mutation.
A single injection partially restored their hearing at very low frequencies, and also reduced head tossing, a behaviour caused by impaired balance.
"These effects were sustained for several months, providing evidence that congenital deafness can be effectively overcome by treatment early in development to correct gene expression," the study says.
After the experiment, the mice were dissected, and their cochleas were found to have grown some hair cells.
The success of antisense oligonucleotides adds a further weapon in the quest to overcome deafness.
Last month, doctors at the Massachusetts Eye and Ear and Harvard Medical School reported on a gene drug that transformed cells in the cochlea into hair cells.
In 2012, investigators at the University of California, San Francisco targeted a fix for a faulty version of a gene called VGLUT3. The gene controls a protein that is vital for hair cells to send the signals they pick up.
AFP
Tue Feb 05 2013
![In mice, gene therapy boosts hope for the deaf In mice, gene therapy boosts hope for the deaf](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/http://img.astroawani.com/2013-02/51360024865_295x200.jpg)
- file pic
![Berita tempatan pilihan sepanjang hari ini Berita tempatan pilihan sepanjang hari ini](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2023-12/61703329565_TBBERITAx.jpg)
Berita tempatan pilihan sepanjang hari ini
Berikut adalah berita yang paling menjadi tumpuan sepanjang Selasa, 16 Julai 2024.
![Berita antarabangsa pilihan sepanjang hari ini Berita antarabangsa pilihan sepanjang hari ini](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-03/71709993909_TBBERITAx.jpg)
Berita antarabangsa pilihan sepanjang hari ini
Antara pelbagai berita luar negara yang disiarkan di Astro AWANI, berikut adalah antara yang paling menjadi tumpuan sepanjang hari ini.
![Ekonomi China teruskan momentum pemulihan Ekonomi China teruskan momentum pemulihan](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2023-01/71674060668_ChinaPopulation.jpg)
Ekonomi China teruskan momentum pemulihan
Ekonomi China meneruskan momentum pemulihan dan trend perkembangan ke arah baik dengan operasinya kekal stabil secara keseluruhannya pada separuh pertama tahun ini.
![PPZ-MAIWP catat RM511 juta kutipan zakat tahun ini, naik 10 peratus PPZ-MAIWP catat RM511 juta kutipan zakat tahun ini, naik 10 peratus](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-04/61714481430_TBNAIM.jpg)
PPZ-MAIWP catat RM511 juta kutipan zakat tahun ini, naik 10 peratus
PPZ-MAIWP mencatat kutipan zakat sebanyak RM511 juta dari Januari hingga Jun tahun ini dengan peningkatan sebanyak 10 peratus berbanding tempoh sama pada 2023.
![Empat terbunuh, puluhan cedera dalam protes antikuota di Bangladesh Empat terbunuh, puluhan cedera dalam protes antikuota di Bangladesh](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/71721144143_TBBANGLADESHCAMPUS.jpg)
Empat terbunuh, puluhan cedera dalam protes antikuota di Bangladesh
Abu Sayeed, seorang daripada penyelaras dan pelajar di Universiti Begum Rokeya di Rangpur utara, terbunuh semasa pertempuran dengan polis.
![28 orang termasuk 5 orang awam, 10 askar, terbunuh dalam tempoh 24 jam di Pakistan 28 orang termasuk 5 orang awam, 10 askar, terbunuh dalam tempoh 24 jam di Pakistan](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/51721144906_TBMAPBANNU.jpg)
28 orang termasuk 5 orang awam, 10 askar, terbunuh dalam tempoh 24 jam di Pakistan
Tentera menuding jari kepada kumpulan Hafiz Gul Bahadur dari Tehreek-e-Taliban Pakistan (TTP) yang diharamkan.
![Misi ekonomi produk agrikomoditi ke India perkukuh hubungan dua hala Misi ekonomi produk agrikomoditi ke India perkukuh hubungan dua hala](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/61721130378_JohariAbdulGhani.jpg)
Misi ekonomi produk agrikomoditi ke India perkukuh hubungan dua hala
KPK akan mengadakan Misi Ekonomi Produk Agrikomoditi Malaysia ke India pada 17-18 Julai ini.
![Golongan belia pemacu penting bentuk masa depan industri pembuatan Malaysia - FMM Golongan belia pemacu penting bentuk masa depan industri pembuatan Malaysia - FMM](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-05/41715247870_SohThianLaijpg.jpg)
Golongan belia pemacu penting bentuk masa depan industri pembuatan Malaysia - FMM
Pemimpin perniagaan dan usahawan daripada golongan belia merupakan pemacu penting yang akan membentuk masa depan industri pembuatan Malaysia, kata Presiden Persekutuan Pekilang-Pekilang Malaysia.
AWANI Tonight: 16 July 2024
#AWANITonight with @Hafiz_Marzukhi
1. Govt mulls amending Penal Code to deal with cyberbullying
2. England's Southgate resigns after Euro 2024 Final defeat
#AWANIEnglish #AWANINews
1. Govt mulls amending Penal Code to deal with cyberbullying
2. England's Southgate resigns after Euro 2024 Final defeat
#AWANIEnglish #AWANINews
![9,241 pelajar Palestin terbunuh dalam serangan Israel sejak 7 Oktober 9,241 pelajar Palestin terbunuh dalam serangan Israel sejak 7 Oktober](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-06/81718630490_Smokerises.jpg)
9,241 pelajar Palestin terbunuh dalam serangan Israel sejak 7 Oktober
9,318 pelajar terbunuh dan 14,671 lagi cedera di Semenanjung Gaza manakala di Tebing Barat, 103 pelajar terbunuh dan 505 lagi cedera.