NEW YORK: For the first time, a pig kidney has been transplanted into a human without triggering immediate rejection by the recipient's immune system, a potentially major advance that could eventually help alleviate a dire shortage of human organs for transplant.
The procedure done at NYU Langone Health in New York City involved use of a pig whose genes had been altered so that its tissues no longer contained a molecule known to trigger almost immediate rejection.
The recipient was a brain-dead patient with signs of kidney dysfunction whose family consented to the experiment before she was due to be taken off of life support, researchers told Reuters.
For three days, the new kidney was attached to her blood vessels and maintained outside her body, giving researchers access to it.
Test results of the transplanted kidney's function "looked pretty normal," said transplant surgeon Dr. Robert Montgomery, who led the study.
The kidney made "the amount of urine that you would expect" from a transplanted human kidney, he said, and there was no evidence of the vigorous, early rejection seen when unmodified pig kidneys are transplanted into non-human primates.
The recipient's abnormal creatinine level - an indicator of poor kidney function - returned to normal after the transplant, Montgomery said.
In the United States, nearly 107,000 people are presently waiting for organ transplants, including more than 90,000 awaiting a kidney, according to the United Network for Organ Sharing. Wait times for a kidney average three-to-five years.
Researchers have been working for decades on the possibility of using animal organs for transplants, but have been stymied over how to prevent immediate rejection by the human body.
Montgomery's team theorized that knocking out the pig gene for a carbohydrate that triggers rejection - a sugar molecule, or glycan, called alpha-gal - would prevent the problem.
The genetically altered pig, dubbed GalSafe, was developed by United Therapeutics Corp's Revivicor unit. It was approved by the U.S. Food and Drug Administration in December 2020, for use as food for people with a meat allergy and as a potential source of human therapeutics.
Medical products developed from the pigs would still require specific FDA approval before being used in humans, the agency said.
Other researchers are considering whether GalSafe pigs can be sources of everything from heart valves to skin grafts for human patients.
The NYU kidney transplant experiment should pave the way for trials in patients with end-stage kidney failure, possibly in the next year or two, said Montgomery, himself a heart transplant recipient. Those trials might test the approach as a short-term solution for critically ill patients until a human kidney becomes available, or as a permanent graft.
The current experiment involved a single transplant, and the kidney was left in place for only three days, so any future trials are likely to uncover new barriers that will need to be overcome, Montgomery said. Participants would probably be patients with low odds of receiving a human kidney and a poor prognosis on dialysis.
"For a lot of those people, the mortality rate is as high as it is for some cancers, and we don't think twice about using new drugs and doing new trials (in cancer patients) when it might give them a couple of months more of life," Montgomery said.
The researchers worked with medical ethicists, legal and religious experts to vet the concept before asking a family for temporary access to a brain-dead patient, Montgomery said.
Reuters
Wed Oct 20 2021
![US surgeons successfully test pig kidney transplant in human patient US surgeons successfully test pig kidney transplant in human patient](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2021-10/61634701987_pigkidney.jpg)
The surgical team examines the pig kidney for any signs of hyperacute rejection, as the organ was implanted outside the body to allow for observation and tissue sampling. - Joe Carrotta for NYU Langone Health/Handout via REUTERS
![Pertubuhan kebajikan New Zealand mohon maaf edar gula-gula bercampur dadah Methamphetamine Pertubuhan kebajikan New Zealand mohon maaf edar gula-gula bercampur dadah Methamphetamine](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-08/41723674988_pineapplesweetsme.jpg)
Pertubuhan kebajikan New Zealand mohon maaf edar gula-gula bercampur dadah Methamphetamine
Auckland City Mission secara tidak sengaja telah mengagihkan gula-gula bercampur Methamphetamine yang boleh membawa maut melalui pek makanan.
Pesakit buah pinggang di Gaza hadapi kekurangan mesin dialisis
Pesakit buah pinggang di Gaza menghadapi kekurangan peralatan dialisis dan bekalan perubatan yang teruk di Khan Younis.
Kekejaman zionis: Hamas hilang kepercayaan A.S jadi pengantara gencatan senjata
Hamas hilang kepercayaan terhadap keupayaan Amerika Syarikat untuk menjadi pengantara gencatan senjata di Gaza.
Kekejaman zionis: Hamas tidak ambil bahagian rundingan gencatan senjata baharu
Hamas tidak akan mengambil bahagian dalam pusingan baharu rundingan gencatan senjata Gaza yang dijadualkan di Qatar, pada Khamis.
Malaysia kecam pencerobohan Israel ke atas Masjid Al-Aqsa
Wisma Putra dalam satu kenyataan pada Rabu berkata perbuatan keji ini yang dilakukan di bawah perlindungan pasukan keselamatan Israel, merupakan pencerobohan serius terhadap satu daripada tapak paling suci Islam.
![WHO isytihar mpox sebagai kecemasan kesihatan awam global WHO isytihar mpox sebagai kecemasan kesihatan awam global](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-08/41723675747_Mpoxvirus.jpg)
WHO isytihar mpox sebagai kecemasan kesihatan awam global
Ini merupakan pengisytiharan kali kedua dalam tempoh dua tahun berikutan wabak yang bermula di Congo sudah merebak ke negara jiran.
![Turkiye akan terus tingkatkan tekanan ke atas Israel - Presiden Erdogan Turkiye akan terus tingkatkan tekanan ke atas Israel - Presiden Erdogan](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-08/81723674774_TayyipEMahmoudAbbas.jpg)
Turkiye akan terus tingkatkan tekanan ke atas Israel - Presiden Erdogan
Erdogan maklumkan kepada Presiden Mahmoud Abbas, Turkiye akan terus sokong perjuangan Palestin.
![Bekas pemimpin Bangladesh, Hasina didakwa lakukan genosid Bekas pemimpin Bangladesh, Hasina didakwa lakukan genosid](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2016-07/71467442821_SheikhHasina.jpg)
Bekas pemimpin Bangladesh, Hasina didakwa lakukan genosid
Sheikh Hasina didakwa melakukan "genosid dan jenayah terhadap kemanusiaan" semasa beberapa minggu protes ganas yang mengakibatkan ratusan orang terbunuh.
![Fadillah tiba di Peru untuk hadiri mesyuarat menteri-menteri tenaga APEC 2024 Fadillah tiba di Peru untuk hadiri mesyuarat menteri-menteri tenaga APEC 2024](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-08/51723674456_FadillahYusof.jpg)
Fadillah tiba di Peru untuk hadiri mesyuarat menteri-menteri tenaga APEC 2024
Timbalan Perdana Menteri Fadillah akan mengetengahkan pendirian Malaysia dalam melaksanakan usaha peralihan tenaga negara.
![Lawatan PM Anwar ke India dijangka kukuhkan hubungan ekonomi - Ramanan Lawatan PM Anwar ke India dijangka kukuhkan hubungan ekonomi - Ramanan](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/61721630406_TBAnwarIbrahim.jpg)
Lawatan PM Anwar ke India dijangka kukuhkan hubungan ekonomi - Ramanan
Perdana Menteri Anwar dijadualkan membuat lawatan rasmi pertama ke India dari 19 hingga 20 Ogos.