Researchers in the USA have discovered that reducing the amount of the L-glutamine amino acid in the body can block the growth of colorectal cancer tumors in mice. The first clinical trials on humans are due to begin this summer.
L-glutamine is a non-essential amino acid found in eggs, meat, fish, dairy products, cereals and pulses. It is also found in raw spinach and parsley, as well as Asian miso. It's sometimes recommended as a dietary supplement, notably for reducing intestinal permeability.
Recent research has established that cancerous tumors rely on L-glutamine to survive and grow.
In this latest study, scientists found that a subset of colorectal cancer cells containing a genetic mutation called PIK3CA -- a commonly occurring mutation in cancer cells -- were particularly high consumers of L-glutamine when growing.
When Professor Zhenghe John Wang and his team reduced the amount of L-glutamine available to these "mutant" cancer cells growing in laboratory dishes, the cells died.
This discovery, outlined in the journal Nature Communications, inspired the scientists to investigate the effects of depriving the cells of L-glutamine in mice with colorectal cancer tumors.
They found that when mice were given a compound to block the metabolism of L- glutamine, the tumors stopped growing. However, this effect was not seen in tumors that did not contain the PIK3CA mutation.
The findings, which are currently the subject of a patent application, could lead to the development of a new drug to suppress tumor growth.
The first clinical trials of an L-glutamine inhibitor in human patients with advanced stage colorectal cancer will begin this summer.
Over one million men and women are living with colorectal cancer in the USA.
AFP RELAXNEWS
Sat Jul 23 2016
![Researchers successfully block colon cancer tumor growth Researchers successfully block colon cancer tumor growth](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/http://img.astroawani.com/2016-07/71469243848_ColonGeneric.jpg)
Recent research has established that cancerous tumors rely on L-glutamine to survive and grow.
![Pelan Transformasi Air sasar tingkatkan air bersih, liputan sistem kumbahan - Fadillah Pelan Transformasi Air sasar tingkatkan air bersih, liputan sistem kumbahan - Fadillah](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/81721017239_TBFADILLAH.jpg)
Pelan Transformasi Air sasar tingkatkan air bersih, liputan sistem kumbahan - Fadillah
Pelan Transformasi Air sasar tingkatkan air bersih, tingkatkan liputan sistem kumbahan - Fadillah
![Warga Thailand mengaku tidak bersalah seleweng diesel Warga Thailand mengaku tidak bersalah seleweng diesel](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/41721103547_WargaThailandWitt.jpg)
Warga Thailand mengaku tidak bersalah seleweng diesel
Seorang warga Thailand mengaku tidak bersalah di Mahkamah Sesyen Alor Setar atas pertuduhan menyeleweng 322 liter minyak diesel.
Lilitan reben putih tak langgar peraturan - Timbalan Speaker
Ramli berkata, perkara itu juga adalah merupakan keputusannya dan bukan dibuat oleh Yang Dipertua Dewan Rakyat, Tan Sri Johari Abdul.
Kos pampasan tanah fasa 1B proses projek LPB Sabah RM1.2 bilion - Alexander
Anggaran kos pengambilan balik tanah bagi keseluruhan Fasa 1B proses pengambilan tanah dan penilaian pampasan tanah bagi Projek Lebuh Raya Pan Borneo Sabah (LPB Sabah) berjumlah RM1.2 bilion.
KR sedia tambah baik SOP pembinaan lebuhraya
Alaxender berkata kementerian bersedia untuk mendedahkan laporan kajian insiden jika ia melibatkan kemalangan berskala besar dan meragut nyawa.
![Reman suspek kes keropok beracun disambung dua hari Reman suspek kes keropok beracun disambung dua hari](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/81721107133_keropokberacunrem.jpg)
Reman suspek kes keropok beracun disambung dua hari
Tempoh reman terhadap seorang pemilik kebun disambung selama dua hari, bagi membantu siasatan kematian dua kanak-kanak yang meninggal dunia akibat makan keropok beracun.
KPM alukan pesara guru ajar Bahasa Inggeris
Jelas Fadhlina Sidek pesara-pesara guru telah banyak membantu usaha KPM dalam meningkatkan PdP bahasa Inggeris termasuk melalui Program Highly Immersive Programme Mentor (HIP Mentor).
![Tidak perlu lagi kemas kini status COVID-19 dalam MySejahtera - KKM Tidak perlu lagi kemas kini status COVID-19 dalam MySejahtera - KKM](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2024-07/81721100784_TBmysj.jpg)
Tidak perlu lagi kemas kini status COVID-19 dalam MySejahtera - KKM
Jika positif COVID-19 melalui ujian kendiri, pesakit boleh mengunjungi klinik dan hospital berdekatan bagi mendapatkan pengesahan.
![Mayat hampir reput dijumpai di rumah usang Mayat hampir reput dijumpai di rumah usang](https://resizer-awani.eco.astro.com.my/tr:w-177,h-100,q-100,f-auto/https://img.astroawani.com/2023-12/41702437730_maut.jpg)
Mayat hampir reput dijumpai di rumah usang
Mayat hampir reput ditemui di sebuah rumah usang di Kesang Laut, berdekatan pusat timbang Jabatan Pengangkutan Jalan (JPJ) pada Ahad.
Wanita dakwa dituduh Rafizi fail saman
Seorang wanita memfailkan saman terhadap Menteri Ekonomi, Rafizi Ramli bagi menuntut permohonan maaf secara terbuka berhubung dakwaan bahawa wanita berkenaan ialah isteri kepada bekas menteri yang dikaitkan dengan isu kapal tempur pesisir (LCS).
Bagaimanapun, Rafizi bergantung kepada pembelaan justifikasi berkata bersedia membuktikan kenyataan di mahkamah termasuk perlindungan bersyarat dan ulasan yang saksama terhadap saman fitnah yang difailkan oleh Zainab Mohd Salleh.
Bagaimanapun, Rafizi bergantung kepada pembelaan justifikasi berkata bersedia membuktikan kenyataan di mahkamah termasuk perlindungan bersyarat dan ulasan yang saksama terhadap saman fitnah yang difailkan oleh Zainab Mohd Salleh.